Effect of siRNA nuclease stability on th
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Derek W. Bartlett; Mark E. Davis
📂
Article
📅
2006
🏛
John Wiley and Sons
🌐
English
⚖ 306 KB
👁 2 views
## Abstract Small interfering RNA (siRNA) molecules achieve sequence‐specific gene silencing through the RNA interference (RNAi) mechanism. Here, live‐cell and live‐animal bioluminescent imaging (BLI) is used to directly compare luciferase knockdown by unmodified and nuclease‐stabilized siRNAs in r