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Quantifying Structural and Functional Restraints on Amino Acid Substitutions in Evolution of Proteins

โœ Scribed by V. Chelliah; T. L. Blundell


Book ID
106372793
Publisher
Springer
Year
2005
Tongue
English
Weight
315 KB
Volume
70
Category
Article
ISSN
0006-2979

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An important challenge in translational bioinformatics is to understand how genetic variation gives rise to molecular changes at the protein level that can precipitate both monogenic and complex disease. To this end, we compiled datasets of human diseaseassociated amino acid substitutions (AAS) in t