Recessive mutant gene c in axolotls results in a failure of the heart to function because of abnormal embryonic induction processes. The myocardium in this mutant lacks organized sarcomeric myofibrils. The present study was undertaken to determine if developmental abnormalities were evident in other
Quantification of tropomyosin by radioimmunoassay in developing hearts of cardiac mutant axolotls,Ambystoma mexicanum
β Scribed by Pamela B. Moore; Larry F. Lemanski
- Publisher
- Springer Netherlands
- Year
- 1982
- Tongue
- English
- Weight
- 436 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0142-4319
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Recessive mutant gene c for "cardiac nonfunction" in axolotls results in an absence of normal heart contractions in affected embryos due to a failure of myofibril formation. In the present study, the intermediate filament protein, desmin, is compared in developing normal and mutant hearts by means o
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## Abstract The Mexican axolotl, __Ambystoma mexicanum__, is an excellent animal model for studying heart development because it carries a naturally occurring recessive genetic mutation, designated gene c, for cardiac nonfunction. The double recessive mutants (__c__/__c__) fail to form organized my
When homozygous, recessive mutant gene c in Ambystoma mexicanum results in a failure of embryonic heart function. This failure is apparently due to abnormal inductive influences from the anterior endoderm resulting in an absence of normal sarcomeric myofibril formation. Biochemical and immunofluores