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Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection

✍ Scribed by Andrew Menelaou; Mark R. Hutchinson; Ingvild Quinn; Anders Christensen; Andrew A. Somogyi


Book ID
108497418
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
404 KB
Volume
785
Category
Article
ISSN
1873-376X

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An analytical method is described for the quantification of S-nitrosoglutathione (GSNO), a potent physiological vasodilator and inhibitor of platelet aggregation, in the presence of a high excess of reduced glutathione (GSH). The method is based on the quantitative elimination of GSH by N-ethylmalei