Quantification of superparamagnetic iron oxide-mediated signal intensity change in patients with liver cirrhosis using T2 and T2* mapping: A preliminary report
✍ Scribed by Yong Eun Chung; Mi-Suk Park; Myoung Soo Kim; Eunju Kim; Jaeseok Park; Ho-Taek Song; Jin Young Choi; Myeong-Jin Kim; Ki Whang Kim
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 724 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose:
To quantify the accumulation of superparamagnetic iron oxide (SPIO) in patients with and without liver cirrhosis using T2 and T2* mapping.
Materials and Methods:
We enrolled 10 patients without liver cirrhosis and 30 patients with liver cirrhosis (Child‐Pugh class A, n = 18; and B/C, n = 12). T2 and T2* mapping were performed before and after SPIO administration. The reductions in T2 (ΔT2) and T2* (ΔT2*) after SPIO administration were compared between the control and liver cirrhosis groups and the control, Child‐Pugh A, and Child Pugh B/C groups.
Results:
There were significant differences in ΔT2 (22.2 ± 4.4 and 15.1 ± 7.0) and ΔT2* values (24.3 ± 3.3 and 16.8 ± 8.1) (P = 0.005 and P < 0.001) between the control and the liver cirrhosis groups. There was a significant difference in the ΔT2* between the Child‐Pugh A and Child‐Pugh B/C groups (P < 0.001) and in the ΔT2 and ΔT2* between the control and Child‐Pugh B/C groups (P = 0.018 and P < 0.001).
Conclusion:
ΔT2 and ΔT2* are significantly larger in patients without liver cirrhosis than those with liver cirrhosis. ΔT2* is also significantly larger in Child‐Pugh class A patients than those in Child‐Pugh B/C. J. Magn. Reson. Imaging 2010;31:1379–1386. © 2010 Wiley‐Liss, Inc.