Quantification of SCH 39166, a novel selective D1 dopamine receptor antagonist, in rat brain and blood
✍ Scribed by J. Hietala; T. Seppälä; J. Lappalainen; E. Syvälahti
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 436 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0033-3158
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SCH 39166 [(-)-trans-6,7,7a,8,9, 13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo(d)naphtho-(2,1- b)azepine] is a new more selective dopamine D-1 receptor antagonist than the widely used SCH 23390. [11C]SCH 39166 was prepared by N-methylation of the desmethyl compound SCH 40853 [(-)-trans-6,7,7a,8
Behavioral and biochemical studies suggest that a negative interaction exists between adenosine A 1 and dopamine D 1 receptors in the brain and that this may contribute to the psychomotor effects of adenosine receptor agonists and antagonists. We examined the functional significance of A 1 and D 1 r