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Quantification of pinosylvin in rat plasma by liquid chromatography–tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study

✍ Scribed by Yeo, Samuel Chao Ming; Luo, Wenxia; Wu, Jinzhu; Ho, Paul C.; Lin, Hai-Shu

Book ID: 123049109
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 916 KB
Volume: 931
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2013.05.023

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to