Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia
β Scribed by H. Ichinose; T. Ohye; K. Fujita; F. Pantucek; K. Lange; P. Riederer; T. Nagatsu
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 734 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1435-1463
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Aromatic l-amino acid decarboxylase (AADC) and tyrosine hydroxylase (TH) are involved in the synthesis of dopamine and other monoamine neurotransmitters, and their activities can be regulated by a number of physiological stimuli. An interesting finding has been that (2)-deprenyl and some other irrev
The present study examined the effects of the antiparkinsonian drug budipine on dopamine synthesis and release from L-DOPA in the substantia nigra of reserpine-treated rats. Budipine (at 100 microM, but not 10 microM) applied by reverse dialysis to the nigra caused a small and significant rise in do