Quantification of liver blood volume: comparison of ultra short ti inversion recovery echo planar imaging (ulstir-epi), with dynamic 3d-gradient recalled echo imaging
✍ Scribed by Heidi C. Schwickert; Timothy P. L. Roberts; David M. Shames; Cornelis F. Van Dijke; Alexander Disston; Andreas Mühler; Jeffry S. Mann; Robert C. Brasch
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 972 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
An ultra‐short TI inversion recovery echo‐planar imaging (ULSTIR‐EPI) sequence was designed to reduce the influence of water exchange on fractional tissue blood volume (BV) estimation by measurement of T~1~‐changes induced by a gadolinium‐based macromolecular contrast medium (MMCM). Fractional liver BV in rats, estimated by ULSTIR‐EPI was compared for accuracy to a fast T~1~‐weighted three‐dimensional gradient‐echo (3D‐SPGR, 3D‐spoiled gradient recalled acquisition in a steady state) sequence using an in vitro inductively coupled plasma atomic emission spectroscopy (ICP‐AES) assay for BV as a standard. Liver images for fractional BV estimation were acquired in eight rats using both ULSTIR‐EPI and 3D‐SPGR before and after (within 3 to 12 min) intravenous bolus administration of albumin‐Gd‐DTPA~30~ (0.05 mmol Gd/kg). Whereas both MR techniques may be useful for fractional tissue BV estimation, ULSTIR‐EPI offers certain advantages including greater accuracy, direct T~1~ maps, and minimization of transendothelial proton exchange effects. 3D‐SPGR imaging offers better spatial resolution, current availability on standard clinical MR systems, and acceptable accuracy.