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Quantification of l-glutamine using Escherichia coli glutamate synthase: A sensitive fluorometric assay

✍ Scribed by Richard E. Miller


Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
568 KB
Volume
75
Category
Article
ISSN
0003-2697

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✦ Synopsis


A simple, sensitive fluorometric assay for L-glutamine is described. r-Glutamine is quantified by measuring the amount of NADPH oxidized in the presence of a glutamine-containing sample (2-20 nmol), 5 mM a-ketoglutarate, 1 mM EDTA. 63 PM NADPH. and purified Escherichia co/i glutamate synthase (EC 2.6.1.53). High concentrations of L-glutamate and ammonia do not interfere. The method has been applied to quantification of L-glutamine in serum.