Quantification of IFN-γ produced by human purified NK cells following tumor cell stimulation: Comparison of three IFN-γ assays

THE ROLE OF REACTIVE OXYGEN METABOLITES

THE ROLE OF REACTIVE OXYGEN METABOLITES IN THE TRANSCRIPTIONAL REGULATION OF IFN-γ GENE EXPRESSION BY HISTAMINE IN NK CELLS FOLLOWING IL-2 STIMULATION

✍ THOMAS A. HOUZE; PER-ANDERS LARSSON; KRISTOFFER HELLSTRAND; BENGT GUSTAVSSON 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 284 KB

The secretion of interferon‐γ (IFN‐γ) by natural killer (NK) cells following __in vitro__ stimulation with interleukin‐2 (IL‐2) is inhibited by co‐incubation with autologous monocytes at a transcriptional level by more than sixty‐fold. In this study, we investigate the nature of the inhibitory signa