Quantification of haemoglobin binding of 4,4′-methylenebis(2-chloroaniline)(MOCA) in rats
✍ Scribed by G. Sabbioni; H. -G. Neumann
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 727 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0340-5761
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## Abstract 4,4′‐Methylene‐bis(2‐chloroaniline) (MBOCA), a known carcinogen in several animal species, is frequently found in the urine of humans exposed to the compound in the plastics industry. A knowledge of the metabolism and tissue distribution of MBOCA would be of value in monitoring exposure
Groups of 30 Wistar rats of each sex were treated with 2,2'-methylenebis(4-ethyl-6-terf-butylphenol) (MBEBP) in the diet at levels of 0, 0.03, 0.1 and 0.3% for up to 18 months. In both sexes, survival rates of treated groups were similar to those of the controls. Body weight gain was depressed (0.3%