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Quantification of glucose diffusion in arterial tissues by using optical coherence tomography

✍ Scribed by K. V. Larin; M. G. Ghosn; S. N. Ivers; A. Tellez; J. F. Granada

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 186 KB
Volume: 4
Category: Article
ISSN: 1612-2011
DOI: 10.1002/lapl.200610111

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✦ Synopsis

Several investigations suggest that the early stages of atherosclerosis are modulated by the selective permeability of the vascular tissue to pro-inflammatory molecules of different molecular weights. Up to date, a few experiments have been performed to study the permeability of arterial tissue to different molecules. This is primarily due to an absence of an experimental technique capable of depth-resolved, accurate and sensitive assessment of arterial permeability. In this paper, we report our pilot results on nondestructive quantification of glucose diffusion in animal arteries__in vitro__by using optical coherence tomography (OCT) technique. Permeability of glucose in animal's aorta was estimated to be 1.43±0.24×10^-5^cm/sec from five independent experiments. Obtained results suggest capability of OCT technique for highly sensitive, accurate, and nondestructive monitoring and quantification of agents' diffusion in vascular tissues.

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