Ca 2+ current (L-type) and inward current caused by Ca 2+ release from the sarcoplasmic reticulum and carried by electrogenic Na+/Ca 2+ exchange have been measured in cultured atrial myocytes from hearts of adult guinea-pigs using whole-cell voltage clamp techniques. The pipette solution, used for i
Quantification of calcium release from the sarcoplasmic reticulum in rainbow trout atrial myocytes
โ Scribed by L. Hove-Madsen; A. Llach; L. Tort
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 103 KB
- Volume
- 438
- Category
- Article
- ISSN
- 0031-6768
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Ca2+ release from the sarcoplasmic reticulum (SR) of mammalian cardiac myocytes occurring either due to activation by a depolarization or the resulting transmembrane Ca2+ current (ICa), or spontaneously due to Ca2+ overload has been shown to cause inward current(s) at negative membrane potentials. I
We present a model for predicting the temporal and spatial dependence of [Ca] in the cardiac subsarcolemmal diadic region (cleft), following Ca release from the "feet" of the sarcoplasmic reticulum. This region is modeled as a disc 10 nm thick, 430 nm in radius, with or without Ca binding sites and