Quantification of apolipoprotein A-I and B messenger RNA in heavy drinkers according to liver disease

✍ Scribed by P Mathurin; D Vidaud; M Vidaud; P Bedossa; V Paradis; V Ratziu; J Chaput; T Poynard

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 375 KB
• Volume: 23
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510230107

✦ Synopsis

It has previously been shown that, in heavy drinkers, Apolipoprotein A-I (ApoA-I), a major component of serum apolipoprotein A-I (ApoA-I) levels are closely rehigh-density lipoprotein, is synthesized in equal prolated to the degree of liver injury: they are at a maximum portions by the liver and the intestine. Like the level in patients with steatosis, begin to decrease in patients of high-density lipoprotein the level of ApoA-I has been with fibrosis, and reach a minimum in patients with seshown to be inversely correlated with the development vere cirrhosis. In contrast with serum ApoA-I variations, of coronary artery disease. Variations in serum ApoAserum apolipoprotein B (ApoB) levels are stable. The as-I are also correlated with alcohol consumption and the sessment of messenger RNA (mRNA) levels of ApoA-I and degree of liver disease. 1-4 The stimulatory effects of al-ApoB using a quantitative competitive polymerase chain cohol on ApoA-I secretion may explain the possible reaction (PCR) method was performed in 18 alcoholic cardioprotective effect of alcohol. In effect, serum patients: 8 with normal livers or steatosis (group I), 6 with fibrosis or nonsevere cirrhosis (group II), and 4 ApoA-I is increased in alcoholic patients with normal with severe cirrhosis (group III). For ApoA-I, group I liver or steatosis. 5-8 However, serum ApoA-I is dehad higher serum levels (208.4 { 37.6 mg/dL mean { SE) creased in alcoholic patients with liver fibrosis indeand mRNA levels (0.51 { 0.12) than group II (serum 116 pendently of nutritional parameters. 1,2 { 19 mg/dL, P õ .01, mRNA 0.40 { 0.11, P õ .09) or group

We and others have validated a simple index referred III (serum 56.5 { 28.6 mg/dL, P õ .01, mRNA 0.27 { .02, to as PGA, which includes a specific test for severe liver P Å .008). For ApoB, the three groups had similar serum disease (prothrombin time), a sensitive test for alcohol-