Quality of life in patients with K- RAS wild-type colorectal cancer
β Scribed by Ringash, Jolie; Au, Heather-Jane; Siu, Lillian L.; Shapiro, Jeremy D.; Jonker, Derek J.; Zalcberg, John R.; Moore, Malcolm J.; Strickland, Andrew; Kotb, Rami; Jeffery, Mark; Alcindor, Thierry; Ng, Siobhan; Salim, Muhammad; Sabesan, Sabe; Easaw, Jay C.; Shannon, Jenny; El-Tahche, Fabyolla; Walters, Ian; Tu, Dongsheng; O'Callaghan, Christopher J.
- Book ID
- 125449573
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 336 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Seventy to 40% of KβRAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (antiβEGFR) monoclonal antibodies. Recent data suggested that in presence of IGFβ1 system, altered activation colorectal cancer cells may escape antiβEGF