For more than 30 years the European Organization for Research and Treatment for Cancer (EORTC) has conducted, co-ordinated, and stimulated research on the experimental and clinical bases of treatment of cancer and related problems. For more than a decade the EORTC has included quality of life as an
Quality of life as an outcome in clinical trials and cancer care: A primer for surgeons
β Scribed by Giles F. Whalen; Carol Estwing Ferrans
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 92 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-4790
- DOI
- 10.1002/jso.1107
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Assessment of health related quality of life (QOL) has become an important endpoint in many clinical trials of cancer therapy. Most of these studies entail multiple QOL scales that are assessed repeatedly over time. As a result, the problem of multiple comparisons is a primary analytic challenge wit
We summarize issues that arise when considering quality of life (QOL) data in cancer clinical trials, especially those related to missing data. We describe different types of missing data mechanisms, and discuss ways of assessing and testing missing data mechanisms. A section on presentation of stud
Measurement of quality of life (QOL) in cancer clinical trials has increased in recent years as more groups realize the importance of such endpoints. A key problem has been missing data. Some QOL data may unavoidably be missing, as for example when patients are too ill to complete forms. Other impor