Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies
✍ Scribed by Leslie G. Dodd; Nour Sneige; Yolanda Villarreal; Christina V. Fanning; Gregg A. Staerkel; Nancy P. Caraway; Elvio G. Silva; Ruth L. Katz
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 801 KB
- Volume
- 9
- Category
- Article
- ISSN
- 8755-1039
No coin nor oath required. For personal study only.
✦ Synopsis
A s part o f a quality assurance study, we reviewed 223 cases of simultaneously sampled cervical smears and biopsies that showed a significant lack of correlation for squamous dysplasia or carcinoma. In 1.53 ofthe 223 cases (68.6%), the cytology was negative and the biopsy positive. After review ofthe specimens, errors in this group were found to be of the following types: sampling 64%, interpretive 29%, and combined sampling and interpretive 7%. In the remaining 70 cases (31.4%), the biopsy was negative and the Papanicolaou smear positive. In these cases, the following types of errors occurred: sampling 54%, interpretive 33 %, and combination 13%. Twenty-nine of these 70 patients showed dysplasia on follow-up material. These findings indicate there are a significant number offalse-negative Papanicolaou smears, mostly because of sampling problems. There are few false-positives. In cases ofpositive Papanicolaou and negative biopsy, dysplasia is likely to be present in subsequent samples. Diagn Cytopathol 1993;9:138-144.