Quality assurance and quality control methods for animal and human applications of no-carrier-added 6-[18F]fluorodopa for PET investigations of dopaminergic systems

An improved synthesis of no-carrier-adde

An improved synthesis of no-carrier-added (NCA) 6-[18F]Fluoro-l-DOPA and its remote routine production for PET investigations of dopaminergic systems

✍ Guvvala N. Reddy; Marc Haeberli; Hans-Frieder Beer; August P. Schubiger 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 452 KB

A detailed and improved synthetic procedure to produce NCA 6-['"F]fluoro-L-dopa (6-FDOPA) is described. A remotely-operable system for its routine production was built and tested for stable and reproducible tracer production (n > 20). Commercially available 6-nitroveratraldehyde or 6-nitropiperonal