Quality-adjusted survival analysis of Radiation Therapy Oncology Group (RTOG) 90-03: Phase III randomized study comparing altered fractionation to standard fractionation radiotherapy for locally advanced head and neck squamous cell carcinoma
✍ Scribed by Andre A. Konski; Kathryn Winter; Bernard F. Cole; Kie-Kian Ang; Karen K. Fu
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 186 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background.
To evaluate quality‐adjusted survival (QAS) of patients with locally advanced squamous cell carcinoma of the head and neck treated with 4 different radiation fractionation schedules.
Methods.
QAS was calculated using the quality‐adjusted time without toxicity or relapse (Q‐TWiST) methodology. Utilities (patient preferences for certain health states) were obtained by threshold analysis. Q‐TWiST therefore equaled TWiST + ([weight for toxicity] × [time spent in toxicity]) + ([weight for relapse] × [time spent in relapse]).
Results.
A statistically significant increase in QAS existed for patients treated with hyperfractionated radiotherapy compared with standard fractionated radiotherapy (SFX) with a toxicity utility ≥0.57 and relapse utility ≤0.72. No statistically significant difference was observed for patients treated with the other 2 fractionation schedules compared with SFX.
Conclusion.
Q‐TWiST analysis identified patient groups that would benefit from more aggressive therapy. Further investigation with patient‐generated utilities is needed. © 2008 Wiley Periodicals, Inc. Head Neck, 2009