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Qualitative method for dantrolene and a related metabolite in urine

✍ Scribed by John D. Conklin; R. J. Sobers

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
239 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

A qualitative method is described for the determination of dantrolene, amew skeletal muscle relaxant, and a related nonreduced metabolite in human urine. The method consists of the direct extraction of the drug and the metabolite from urine into nitromethane. Addition of a hyamine hydroxide solution to the solvent extract from urines containing the drug and the metabolite results in a yellow color which is linearly related to the amount of drug and metabolite present. A yellow color is not apparent when the alkaline solution is added to solvent extracts from control urine. The method is specific for dantrolene plus the nonreduced metabolite in the presence of a reduced metabolite. Data obtained from urine specimens, collected from humans receiving sodium dantrolene and analyzed by the qualitative method, are also presented.

Keypbrasea 0 Dantrolene and metabolite-qualitative colorimetric determination in urine 0 Colorimetry-qualitative determination of dantrolene and metabolite in urine * Hitachi model 139.

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