β Scribed by E. Ivashkiv
No coin nor oath required. For personal study only.
A qualitative colorimetric test has been developed for the identification and differentiation of fludrocortisone acetate, triamcinolone, and triamcinolone acetonide in pharmaceutical formulations. The test is based o n a newly discovered reaction for fluorinated steroids and depends upon the formation of an amber color from fludrocortisone acetate, a yellow chromogen from hydrolyzed triamcinolone, and a pink color from triamcinolone acetonide by reaction of phenol, hydroquinone, and the phosphoric-sulfuric acid mixture.
ANY color reactions of steroids are used in M qualitative tests to demonstrate the presence of these various steroids in pharmaceutical preparations. For example, nz-dinitrobenzene-potassium hydroxide ( ) and 2,6-di-tert-butyl-p-cresol (2) are useful identity tests for various fluorinated steroids.
This investigation is a study of the newly discovered color reaction for fluorinated steroids with phenol, hydroquiiione, and the phosphoric-sulfuric acid rnisture as a specific niethod of identification and differentiation of fludrocortisone acetate, triamcinolone, and triamcinolone acetonide in pliarrnnceutical formulations.
π SIMILAR VOLUMES
The cytogenetic potential of 10 sex steroids (cyproterone acetate, drospirenone, gestodene, cyclodiol, cyclotriol, ethinylestradiol, atamestane, lilopristone, onapristone and propylmesterolone) with various medical indications was determined using the chromosomal aberration test in human lymphocytes