Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry

Identification of impurities in acarbose

Identification of impurities in acarbose by using an integrated liquid chromatography-nuclear magnetic resonance and liquid chromatography-mass spectrometry approach

✍ Predrag Novak; Mario Cindrić; Predrag Tepeš; Snježana Dragojević; Marina Ilijaš; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 817 KB

## Abstract The usefulness of applying an integrated LC‐NMR and LC‐MS approach to acarbose bulk drug impurity profiling is demonstrated. LC‐MS and LC‐NMR methodologies were employed for the online separation and structural elucidation of a final drug product. Combining data provided by the stop‐flo

Characterization of a New Anticancer Age

Characterization of a New Anticancer Agent, EAPB0203, and Its Main Metabolites: Nuclear Magnetic Resonance and Liquid Chromatography–Mass Spectrometry Studies

✍ Lafaille, Florian; Banaigs, Bernard; Inguimbert, Nicolas; Enjalbal, Christine; D 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 1001 KB

Isolation of circulating metabolites in

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

✍ Hong Kim; Wenqing Feng; Tze-Ming Chan; Diane Rindgen; Matthew Bryant; Kathleen A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 3 views

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy One of the major components of modern drug discovery is the structu