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QSAR studies of 8-substituted xanthines as adenosine receptor antagonists

✍ Scribed by IA Doichinova; RN Natcheva; DN Mihailova

Book ID
103629978
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
711 KB
Volume
29
Category
Article
ISSN
0223-5234

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A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. The process, promoted by (bromodimethyl)sulfonium bromide, is mild and efficient and eliminates the need for external oxidants. Yields are good and the process is applicable to a range of subst