QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines

✍ Scribed by Romualdo Benigni; Laura Passerini; Grazia Gallo; Fabrizio Giorgi; Marina Cotta-Ramusino

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 107 KB
• Volume: 32
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/(sici)1098-2280(1998)32:1<75::aid-em9>3.0.co;2-a

✦ Synopsis

In a previous article, we demonstrated that the struc-that 1) in genetic toxicology, it is necessary to sepature -activity relationship model for the mutagenic rately investigate the structure-activity relationships potency of aromatic amines is different from that for for discrimination between positive and negative discriminating between mutagens and nonmuta-chemicals, and the structure-activity relationships gens. In this work, we present further analyses on for the potency of the positive chemicals; 2) in structhe molecular determinants of the mutagenicity of ture -activity studies, it is necessary to investigate aromatic amines. Based on the use of various meth-the degree of homogeneity (congenericity) of apodological approaches, our results indicate that mu-parently similar chemicals in order to assess and tagenic activity is influenced by different molecular describe the various mechanisms of action that may characteristics in different subclasses of aromatic be elicited by the chemicals.