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QSAR and Classification Study of 1,4-Dihydropyridine Calcium Channel Antagonists Based on Least Squares Support Vector Machines

✍ Scribed by Yao, Xiaojun; Liu, Huanxiang; Zhang, Ruisheng; Liu, Mancang; Hu, Zhide; Panaye, A.; Doucet, J. P.; Fan, Botao

Book ID: 125546724
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 151 KB
Volume: 2
Category: Article
ISSN: 1543-8384
DOI: 10.1021/mp050027v

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## Abstract The usefulness of the quantum chemical descriptors, calculated at the level of the RHF theory using 6‐31G basis set for QSAR study of 1,4‐dihydropyridine‐based calcium channel antagonist was examined. A data set containing 45 dihydropyridine derivatives with known activity was used. Mul