The correlation between the molecular electrostatic potential (MEP) on benzofuran inhibitors and the N-myristoyltransferase (Nmt) inhibitory activity is investigated by a three-dimensional quantitative structure -activity relationship (3D-QSAR) approach. To each compound, a Kohonen neural network (K
β¦ LIBER β¦
QSAR analysis of N-myristoyltransferase inhibitors: antifungal activity of benzofurans
β Scribed by Hemantkumar S. Deokar; Purushottamachar Puranik; Vithal M. Kulkarni
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 445 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1054-2523
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MyristoylCoA: protein N-myristoyltransferase (NMT) catalyzes the cotranslational covalent attachment of a rare cellular fatty acid, myristate, to the N-terminal Gly residue of a variety of eukaryotic proteins. The myristoyl moiety is often essential for expression of the biological functions for the