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Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells

โœ Scribed by Xiaofei Wang; Evelyn Perez; Ran Liu; Liang-Jun Yan; Robert T. Mallet; Shao-Hua Yang


Book ID
113502396
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
875 KB
Volume
1132
Category
Article
ISSN
0006-8993

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## Abstract The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP^+^ to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SHโ€SY5Y cells overexpressing IDPm (S1). S1 cells showed higher NADPH and GSH level