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Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues

✍ Scribed by Rames Kamel; Friedrich Schwarzfischer

Publisher
Springer
Year
1975
Tongue
English
Weight
515 KB
Volume
28
Category
Article
ISSN
0340-6717

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✦ Synopsis

A method of starch gel electrophoresis is described which enables detection of 6 isozymes of human pyruvate kinase (PK, E.C.2.7.1.40). Comparing the PK-isozyme patterns of 53 diverse human tumors with those of normal adult and fetal organ tissues, it was found that the isozyme PK I is predominant in all malignant tumors as well as in almost all fetal organs.

πŸ“œ SIMILAR VOLUMES

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Hexokinase isozymes in human neoplastic and fetal tissues: The existence of hexokinase II in malignant tumors and in placenta
✍ R. Kamel; F. Schwarzfischer πŸ“‚ Article πŸ“… 1975 πŸ› Springer 🌐 English βš– 335 KB

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## Abstract Electrophoretic and immunofluorescence analysis were used to study the distribution of pyruvate kinase isozymes in the bovine kidney. Electrophoretic analysis demonstrated the presence of large amounts of K~4~ plus small amounts of K‐M hybrids in cortical, medullary, and papillary secti