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Pyruvate dehydrogenase E3 binding protein deficiency

โœ Scribed by Ruth M. Brown; Rosie A. Head; Garry K. Brown


Book ID
106133627
Publisher
Springer
Year
2002
Tongue
English
Weight
56 KB
Volume
110
Category
Article
ISSN
0340-6717

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Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associat