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Pyrryl-aryl-sulphones: synthesis and anti-HIV activity

โœ Scribed by A. De Montis; M. Doa; A.G. Loi; M. Artico; R. Silvestri; G. Stefancich; S. Massa; P La Colla


Book ID
113259234
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
66 KB
Volume
26
Category
Article
ISSN
0166-3542

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Synthesis of Pyrryl Aryl Sulfones Target
โœ Marino Artico; Romano Silvestri; Giorgio Stefancich; Silvio Massa; Eugenia Pagno ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 581 KB

Various aryl I-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1 -pynyl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitru anti-HIV-1 activity and cytotoxicity of 41 compoun