Synthesis of Pyrryl Aryl Sulfones Target
โ
Marino Artico; Romano Silvestri; Giorgio Stefancich; Silvio Massa; Eugenia Pagno
๐
Article
๐
1995
๐
John Wiley and Sons
๐
English
โ 581 KB
Various aryl I-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1 -pynyl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitru anti-HIV-1 activity and cytotoxicity of 41 compoun