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Pyrrolizidine alkaloid analogues. Preparation of semisynthetic esters of retronecine

โœ Scribed by Hoskins, W. Michael; Crout, David H. G.

Book ID
121192200
Publisher
Royal Society of Chemistry
Year
1977
Weight
1020 KB
Volume
5
Category
Article
ISSN
1472-7781

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๐Ÿ“œ SIMILAR VOLUMES

Dihydropyrrolizine analogues of pyrroliz
Dihydropyrrolizine analogues of pyrrolizidine alkaloids
โœ C.C.J. Culvenor; J.A. Edgar; L.W. Smith; H.J. Tweeddale ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 222 KB

The dihydropyrrolizine analogues (I) of the hepatotoxic pyrrolizidine alkaloids have been suggested as possible toxic metabolites of the alkaloids (1,2,3). The formation of Ehrlich-positive metabolites has been demonstrated (2,4) and the major metabolite of this type formed in the rat from heliotrin