Asymmetric synthesis of 1,3- and 1,3,4-s
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Jing Lin; Wing Hong Chan; Albert W.M Lee; Wai Yeung Wong; Pei Qiang Huang
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Article
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2000
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Elsevier Science
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French
โ 102 KB
Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH 4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3-and 1,3