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Pyrrole Mannich bases as potential antipsychotic agents

โœ Scribed by Scott, Malcolm K.; Martin, Gregory E.; DiStefano, Deena L.; Fedde, Cynthia L.; Kukla, Michael J.; Barrett, Donna L.; Baldy, William J.; Elgin, Robert J.; Kesslick, James M.


Book ID
120332929
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
942 KB
Volume
35
Category
Article
ISSN
0022-2623

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A series of 5-arylidenepyridazin-3-ones substituted in the 2-position by an arylpiperazinoalkyl moiety (2-16) was synthesized and evaluated for analgesic activity. In the phenylbenzoquinone-induced writhing test, Mannich bases 2-14 were the most active compounds (6.1 < or = ED50 < or = 43.0 mg/kg, o