𝔖 Bobbio Scriptorium
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Pyroptosis – a cell death modality of its kind?

✍ Scribed by Oliver Kepp; Lorenzo Galluzzi; Laurence Zitvogel; Guido Kroemer

Book ID
102167856
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
134 KB
Volume
40
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The term “pyroptosis” was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase‐1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis – which can also be triggered by non‐bacterial pathological stimuli – truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.

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