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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

✍ Scribed by Oliver Wirths; Tobias Bethge; Andrea Marcello; Anja Harmeier; Sadim Jawhar; Paul J. Lucassen; Gerd Multhaup; David L. Brody; Thomas Esparza; Martin Ingelsson; Hannu Kalimo; Lars Lannfelt; Thomas A. Bayer

Publisher: Springer
Year: 2009
Tongue: English
Weight: 694 KB
Volume: 117
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s00702-009-0314-x

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## Abstract ## Purpose To investigate the relationship between MR image contrast associated with beta‐amyloid (Aβ) plaques and their histology and compare the histopathological basis of image contrast and the relaxation mechanism associated with Aβ plaques in human Alzheimer's disease (AD) and tra