✦ LIBER ✦

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence

✍ Scribed by Mark D. Andrews; Paul V. Fish; Julian Blagg; Tiffini K. Brabham; Paul E. Brennan; Alison Bridgeland; Alan D. Brown; Peter J. Bungay; Kelly M. Conlon; Nicholas J. Edmunds; Kerry af Forselles; Colleen P. Gibbons; Martin P. Green; Giles Hanton; Mark Holbrook; Alan S. Jessiman; Karin McIntosh; Gordon McMurray; Carly L. Nichols; James A. Root; R. Ian Storer; Michael R. Sutton; Robin V. Ward; Dominique Westbrook; Gavin A. Whitlock

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 638 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.11.120

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Pyrimido[4,5-d]azep

ChemInform Abstract: Pyrimido[4,5-d]azepines as Potent and Selective 5-HT2C Receptor Agonists: Design, Synthesis, and Evaluation of PF-3246799 (I) as a Treatment for Urinary Incontinence.

✍ Mark D. Andrew; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

ChemInform Abstract: Discovery of Novel

ChemInform Abstract: Discovery of Novel Azepine Series of Potent and Selective 5-HT2C Agonists as Potential Treatments for Urinary Incontinence.

✍ Paul E. Brennan; Gavin A. Whitlock; Danny K. H. Ho; Kelly Conlon; Gordon McMurra 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 13 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and Evalu

ChemInform Abstract: Synthesis and Evaluation of Novel 2-Oxo-1,2-dihydro-3-quinolinecarboxamide Derivatives as Potent and Selective Serotonin 5-HT4 Receptor Agonists.

✍ Masaji Suzuki; Yutaka Ohuchi; Hajime Asanuma; Toshie Kaneko; Sadakazu Yokomori; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 2 views

Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-te

Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders

✍ Heather Tye; Stephan G. Mueller; Juergen Prestle; Stefan Scheuerer; Marcus Schin 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 338 KB

The discovery of a novel series of 5-HT(2C) agonists based on a tricyclic pyrazolopyrimidine scaffold is described. Compounds with good levels of in vitro potency and moderate to good levels of selectivity with respect to the 5-HT(2A) and 5-HT(2B) receptors were identified. One of the analogues (7 g

ChemInform Abstract: Design, Synthesis,

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of a Second Generation of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as Potent and Selective A2A Adenosine Receptor Antagonists.

✍ P. G. BARALDI; B. CACCIARI; G. SPALLUTO; M. BERGONZONI; S. DIONISOTTI; E. ONGINI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 2 views

ChemInform Abstract: Imidazo[1,5-a][1,2,

ChemInform Abstract: Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as Potent and Highly Selective GABAA α5 Inverse Agonists with Potential for the Treatment of Cognitive Dysfunction.

✍ Bernd Buettelmann; Theresa M. Ballard; Rodolfo Gasser; Holger Fischer; Maria-Cle 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB