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Pyrimido[4,5-c]pyridazine-5,7(6H, 8H)-diones: Marvelous substrates for study of nucleophilic substitution of hydrogen

✍ Scribed by Alexander F. Pozharskii; Anna V. Gulevskaya

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 278 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420304

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✦ Synopsis

The data on nucleophilic substitution reactions of hydrogen in 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione, its 3-chloride, N 2 -oxide and some other derivatives are reviewed. All these compounds possess a remarkable ability to undergo not only simple functionalizations but also tandem and cascade transformations leading to annelation of various heterocyclic rings.

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