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Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties

✍ Scribed by Martin J. Di Grandi; Kevin J. Curran; Ellen Z. Baum; Geraldine Bebernitz; George A. Ellestad; Wei-Dong Ding; Stanley A. Lang; Miriam Rossi; Jonathan D. Bloom

Book ID: 104364089
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 164 KB
Volume: 13
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(03)00789-3

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✦ Synopsis

The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.

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Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV Protease Inhibitors: A New Class of Heterocycles with Flavin-Like Redox Properties.

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