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Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease

โœ Scribed by D.R. Richardson; P. Ponka


Book ID
114054129
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
1017 KB
Volume
131
Category
Article
ISSN
1532-6543

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Partition coefficients of the iron(III)
โœ J. T. Edward; P. Ponka; D. R. Richardson ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 558 KB

Pyridoxal isonicotinoyl hydrazone and its analogs are orally effective Fe(llI) chelators which show potential as drugs to treat iron overload disease. The present investigation describes the measurement of the partition coefficient of the apochclator and Fe(lll) complex of 20 of these ligands. These