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Pyridoxal 5′ phosphate: A selective inhibitor of oncornaviral DNA polymerases

✍ Scribed by Mukund J. Modak


Book ID
118310556
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
411 KB
Volume
71
Category
Article
ISSN
0006-291X

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Human hepatitis B virus (HBV) DNA polymerase activity was inhibited by pyridoxal 5'-phosphate (PLP) specifically and noncompetitively with respect to deoxythymidine triphosphate (dTTP). NaBH, reduction of PLP-HBV core proteins resulted in the complete inactivation of HBV DNA polymerase, and PLP modi