Pyridine-substituted hydroxythiophenes. II. Alkylation of o-(2-, 3- and 4-pyridyl)-3-hydroxythiophenes: Regiospecific formation of o-pyridyl-3-alkoxythiophenes
✍ Scribed by Yihua Zhang; Anna-Britta Hörnfeldt; Salo Gronowitz
- Book ID
- 112130763
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1993
- Tongue
- English
- Weight
- 447 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-152X
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a b s t r a c t Heating a neat 1:2 mixture of 2-picolylamine and 2-cyanopyridine followed by treatment of the resultant red gummy substance with aqueous KOH resulted in the isolation of 2,4,5-tris(2-pyridyl)imidazole (1a) as the major product and N-(3-(2-pyridyl)imidazo[1,5-a]pyridine)picolinamidine
We have observed an unusual example of cobalt-mediated cyclization of 4-pyridinecarboxaldehyde and 2-nitroaniline to afford 2-(4-pyridyl)benzimidazole under hydro(solvo)thermal conditions. Reaction of Co(NO 3 ) 2 ⅐6H 2 O with 4-pyridinecarboxaldehyde and 2-nitroaniline in ethanol at 120°C gave a cob