Pyridazines, LX. Telesubstitution and Dismutation Reactions in the Series of Phenyl-3-pyridazinylmethane Derivatives

✍ Scribed by Heinisch, Gottfried ;Huber, Thierry

• Book ID: 102368042
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 430 KB
• Volume: 1992
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.199219920105

✦ Synopsis

Abstract

Reactions of 3‐α‐chlorobenzylpyridazine (4) with alkoxides have been found to yield 6‐substituted or 4‐substituted 3‐benzylpyridazines (7a–c, 8a–c) rather than the usual ethers (6a–c). Introduction of an electron‐donating substituent into the 6‐position of the pyridazine nucleus of 4 has been shown to suppress such telesubstitution processes. With phenyl‐3‐pyridazinylmethanol (3), thermally induced dismutation affording 3‐benzylpyridazine (17) and 3‐benzoylpyridazine (11) has been observed.