Pyridazine Analogues of Biologically Active Compounds, VI1,2): Pyrido[2,3-c]pyridazines Structurally Related to Nalidixic Acid

✍ Scribed by Philip Y. Boamah; Norbert Haider; Gottfried Heinisch

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 357 KB
• Volume: 323
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19903230405

✦ Synopsis

Abstract

Synthesis of 8‐alkyl‐5,8‐dihydro‐5‐oxopyrido[2,3‐c]pyridazine‐6‐carboxylic acids 7a–d, starting from 3‐chloro‐4‐pyridazinecarbonitrile, is reported. The novel compounds do not exhibit significant (gyrase‐inhibiting) antibacterial activity.