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Pyrethroid Insecticides as Phosphatase Inhibitors

✍ Scribed by Keri L Fakata; Stanley A Swanson; Roseann L Vorce; Paul M Stemmer

Book ID
119407624
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
519 KB
Volume
55
Category
Article
ISSN
0006-2952

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Further investigation of the structural requirements of a series of benzylphosphonic acid inhibitors of human prostatic acid phosphatase has led to the highly potent series of a-aminobenzylphosphonic acids. The a-benzylaminobenzylphosphonic acid, with an IC~o = 4 nM, exhibited a 3500-fold improvemen