Pyoderma gangrenosum with secondary pyarthrosis following propylthiouracil

✍ Scribed by Troy Darben; Judy Savige; Roger Prentice; Bill Paspaliaris; Jeffrey Chick

• Book ID: 104468940
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 64 KB
• Volume: 40
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.1999.00346.x

✦ Synopsis

The association of pyoderma gangrenosum and arthritic symptoms is well documented. We present a rarely reported variant of this in a 44‐year‐old woman with pyoderma gangrenosum and bilateral large purulent effusions of her knees. She had no evidence of underlying rheumatoid arthritis or a specific seronegative spondyloarthropathy. Of note she had a history of Graves’ disease for which she had been treated with propylthiouracil for 3 years and on investigation at this presentation had a markedly elevated perinuclear antineutrophil cytoplasm antibody (P‐ANCA) level with specificities for IgM myeloperoxidase, IgG elastase and IgG lactoferrin. We believe this patient had pyoderma gangrenosum with secondary sterile pyarthrosis and a P‐ANCA precipitated by propylthiouracil.