Putting T cells to sleep: A new paradigm for immune evasion by persistent viruses

A γ-herpesvirus immune evasion gene allo

A γ-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope

✍ Jason Rice; Brigitte de Lima; Freda K. Stevenson; Philip G. Stevenson 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune