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Putative neurotrophic factors in the protection of cisplatin-induced peripheral neuropathy in rats

✍ Scribed by Frank P.T. Hamers; Roland Gerritsen van der Hoop; Peter A. Steerenburg; Jean P. Neijt; Willem Hendrik Gispen

Book ID
113207672
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
772 KB
Volume
111
Category
Article
ISSN
0041-008X

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In many patients treated with cisplatin a peripheral sensory neuropathy develops. This side-effect is considered dose-limiting, and therefore restricts the total dose of cisplatin that can be administered. Recent in vitro and in vivo studies suggest that recombinant human Glial Growth Factor 2 (rhGG