Reduction in apoptosis has been associated with tumor metastases and response to chemotherapy in breast cancer. We examine the influence of apoptosis status and the expression of antiapoptotic proteins Bcl-2 and Bcl-x(L) on metastatic progression and response to therapy in an experimental model of b
β¦ LIBER β¦
Putative markers of progression as related to histotype and metastatic spread in human breast cancer
β Scribed by Marchetti, Antonio; Butlitta, Fiamma; Pellegrini, Silvia; Campani, Danicla; Bistocchi, Maria
- Book ID
- 122391351
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 71 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0753-3322
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We have examined whether the extended life span of cells induced by Bcl-2 in T 1 ductal breast carcinomas might favor the acquisition and accumulation of genetic alterations that induce lymph node metastases. We analyzed the expression of c-Myc, c-erbB-2 and epidermal growth factor receptor by immun