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Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase

✍ Scribed by Masashi Asai; Chinatsu Hattori; Beáta Szabó; Noboru Sasagawa; Kei Maruyama; Sei-ichi Tanuma; Shoichi Ishiura

Book ID
117053192
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
161 KB
Volume
301
Category
Article
ISSN
0006-291X

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## Abstract Interleukin‐1α (IL‐1α) stimulates a disintegrin and metalloproteinase, ADAM‐17 synthesis, consistent with activation of the soluble fragment of Amyloid Precursor Protein, APP, (sAPPα) in human primary astrocytes. To characterize the mechanism by which IL‐1α promotes the non‐amyloidogeni